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From: Denc 🗡
And wrong of course… The history of RNA drugs dates back to the early 1960s with the discovery of messenger RNA (mRNA), but it wasn't until the late 20th century that research on its therapeutic potential gained significant traction the first FDA-approved RNA drug, "Vitravene" (fomivirsen), was approved in 1998 for treating cytomegalovirus retinitis, marking a major milestone in the field however, the most recent surge in RNA drug development is attributed to the successful development of mRNA COVID-19 vaccines like Pfizer-BioNTech and Moderna, which brought widespread attention to the technology due to their rapid development and effectiveness during the pandemic. Key points in the history of RNA drugs: Early Discoveries (1960s): The discovery of mRNA laid the foundation for RNA therapeutics research, with scientists beginning to explore its potential as a way to control protein production within cells. Development of Delivery Systems (1970s-1990s): Researchers started investigating methods to efficiently deliver RNA molecules into cells, leading to the development of lipid nanoparticles (LNPs) as a primary delivery system. First FDA Approval (1998): "Vitravene" (fomivirsen), an RNA-based drug targeting cytomegalovirus retinitis, became the first FDA-approved RNA therapeutic. RNA Interference Discovery (Late 1990s): The discovery of RNA interference (RNAi), a natural process where cells can silence specific genes using small RNA molecules, further fueled interest in RNA therapeutics. Clinical Trials and Advancements (2000s-2010s): Research expanded to explore RNA therapies for various diseases, including cancer, genetic disorders, and viral infections, with clinical trials investigating different RNA modalities like microRNAs (miRNAs) and small interfering RNAs (siRNAs). COVID-19 Vaccine Breakthrough (2020-2021): The development of mRNA vaccines against COVID-19 by Pfizer-BioNTech and Moderna marked a significant advancement in RNA therapeutics, demonstrating the potential of mRNA technology for large-scale vaccine production.

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